and

“ex.pert (ek’spert): 1) very skillful; having much training and knowledge in some special field; 2) excelling above all others in that special field of knowledge or capability; 3) able to be relied upon to give the correct answer.”

• Prototype in 1979
• First Commercially Available PC System in 1984
• Over a Decade of Continued Reliability
• Routine Clinical Use
• Increasing Around the World into the 21st Century

• History of Excellence
• Modern Radiation Therapy
• Accurate, Ease of Use
• Clear Presentation of Results

• Latest Technology
• Extremely Reliable
• Very Best Value
• Top Quality
• True 3D Calculations

• Dynamic Treatment Planning
• Superior Accuracy
• Finest 3D Computations
• Best Possible Care
• Thousands of Patients
• Increasing Worldwide Acceptance

The prototype for the COMPUTE-Rx PLAN® family of fine software started routine clinical service as a radiation therapy planning system in 1979 and became the basis for the very FIRST commercially available PC based treatment planning system in 1984. For over a decade now, the COMPUTE-Rx PLAN® radiation therapy treatment planning systems have continued to provide the very latest capabilities in radiation therapy treatment planning and have provided reliable, routine radiation therapy treatment planning in ever increasing numbers of clinical facilities around the world as MEDICALIBRATION grows into the 21st century.

The treatment planning programs have always placed special emphasis on the ease of use for the dosimetrist and a clear presentation of the results for the radiotherapist. And now the COMPUTE-Rx PLAN® systems combine this ease and clarity with the latest computer hardware and software to additionally provide superior ease in target definition and localization as well as the accuracy of using the finest in 3D dose computation capabilities. All this will provide You with the best possible planning capabilities so you can give best possible care to your patients at the best possible price.

Throughout its long history of providing accurate dosimetry for thousands of patients worldwide, the many COMPUTE-Rx-PLAN® systems have continued to be based on the latest computer technology and on the best in readily available and extremely reliable standard PC peripherals. Theses treatment planning systems are specifically designed to provide you with the very best value in a top quality radiation therapy treatment planning system that is available today.

MEDICALIBRATION has been here for you and your patients, proudly bringing you quality radiation therapy computer planning capabilities at a reasonable price for over a decade,

MEDICALIBRATION is here for you today, bringing you the very latest capabilities in competent, reliable radiation therapy treatment planning and

MEDICALIBRATION will continue be here for you, with reliability and assurance, well into the 21st century, supporting you in your radiation therapy computing software needs.

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INTRODUCING MEDICALIBRATION’S FAMILY OF FINE PRODUCTS

COMPUTE-Rx-PLAN® can provide you with a complete, proven treatment planning system, ready to meet the daily demands of your department, and at a reasonable cost.

COMPUTE-Rx-PLAN® includes brachytherapy dosimetry, irregular field calculations, complete data input utilities and can include CT capability and water scanner input capability.

COMPUTE-Rx-PLAN® treatment planning software is designed to fulfill all the requirement for modern radiation therapy treatment planning with special emphasis on ease of use for the dosimetrist, and a clear presentation of the calculated results.

All this computing capability is brought to you with the greatest of cost effectiveness on dependable, readily available hardware and standard peripherals.

BRACHYTHERAPY

COMPUTE-Rx-PLAN® brachytherapy dosimetry programs have the special facility to dynamically and precisely specify the planes of the implant calculation by an elegant means of translation and rotation.

COMPUTE-Rx-PLAN® Brachytherapy parameters are directly accessible and are easily edited. Standard configurations are available as protocols for training or pre-planning.

COMPUTE-Rx-PLAN® can calculate 3D dose volumes and then present the results as a 3D volumetric display which can be dynamically rotated so that the dose distribution can be viewed from any orientation.

COMPUTE-Rx-PLAN® PC-3D® now adds the ability to import a complete family of CT images and use the information for a complete 3D dose calculation and display.

Any PC-3D® beam can be angled in any orientation of the gantry, collimator or patient support assembly. The Beam’s Eye View can be used to view the setup and design shielding blocks to exactly match the shape of the user defined tumor or treatment volume.

The PC-3D® dose distribution can be presented overlaying the CT information and can be reformatted in a variety of ways to facilitate the easy visualization of the resulting complete 3D dose distribution.

COMPUTERx-COMP®

COMPUTERx-COMP is the finest missing tissue compensator system available in the world today. It is a complete system for the capture of patient surface contours for use in designing and fabricating missing tissue compensators.

COMPUTERx-COMP uses an elegant means of precision laser triangulation and by use of an exceptionally fast proprietary hardware can collect an entire patient surface in a matter of seconds without having to physically touch the patient. The data can then be used for the fabrication of missing tissue compensators by a variety of means including the use of a numerically controlled milling machine.

Sub-sets of the patient surface data set can be extracted to provide single plane contouring or a full 3-dimensional family of curves for importing into a 3D planning system.

Today, the Medicalibration family of products offering all of the very latest technological capabilities. It is available on the PC environment and often outperforms systems based on much more expensive platforms.

Particular attention has always been given to incorporating procedures for creating the optimum treatment plan as easily and as efficiently as possible with all of the necessary accuracy.

Faster plan calculation by using SIMULTASKING. This unique capability enables the calculation of the various dose matrices as the dosimetrist is manipulating the size or orientation of the beams. This unique capability to constantly calculate the dose distributions is ONLY available with COMPUTE-Rx-PLAN

Faster beam positioning is accomplishes by using the mouse cursor control to “click” on any beam and the “drag” it on the screen immediately to any desired position. A any beam parameter can also be controlled precisely by keyboard input.

Faster computer speed using Latest Hardware Technology: All hardware supplied with a complete COMPUTE-Rx-PLAN is always the very latest, highest speed computer hardware.

Easier using the “Room’s Eye View” to visualize the plan is accomplished by the ability to manipulate and position the viewing positions from any location around the patient.

Easier plan development by using Mnemonic access: The COMPUTERx-PLANÒ uses easy, rapid control of all beam parameters. A single mnemonic keystroke can be used to select then enter any beam parameter quickly and directly.

Easier to setup plans by using Protocols which may be saved and recalled to optimize the dosimetrist time and by using a library of standard shapes which is provided for the dosimetrists to use for training and preplanning.

Accurate dose calculations necessary for clinical application to therapeutic treatment planning is maintained by COMPUTE-Rx-PLAN systems by using proven algorithms to calculate the dose distributions as quickly as possible.

Accurate identification of all beams and structures as well as the relative locations of the tumor or treatment volumes from any viewing position are enabled by Super-graphics visualization.

Accurate Irregular fields can be tailored to the tumor or defined treatment volume by means of the “Beam’s Eye View” screens to enter and define the shielding blocks

Accurate CT number to electron density relationship can be specified by the user or default values can be accepted. This capability is necessary to enable to most accurate dose calculations possible from the available CT information and is not possible or the relationship is assumed on many other CT planning systems. Specifying and editing the relationship is uniquely simply and accurate in the PC-3D system.

Accurate inhomogeneity calculations are accomplished by using an exacting pixel-by-pixel ray tracing to determine the primary and scatter contribution at all points with the special ability to modify the scatter contribution for all inhomogeneities. This capability also then automatically compensates for the decrease in scatter caused by beams that “flash” past the edge surface of the patient. This is a capability which may not even be available in some other systems.

Ease of data assimilation:

Special consideration has been focused on the ease of CT data input. Assimilation of CT information is done in background by downloading from a remote CT scanner via local area network, disk or tapes. Image assimilation and conversion to PC viewing format is done automatically with minimal user involvement.

All assimilated CT images are then available for selection and viewing and are used to define treatment volumes and special interest points. Auto-Tracking™ can automatically track around a pixel density value to define the contour of a structure. The mouse may also be used to specify special areas of interest and to delineate a user defined treatment volume.

The CT windowing capabilities include the ability to do a histogram analysis of the pixel density frequencies. This can be used to select the most optimum CT numbers for viewing or to use to AUTOTRACK™ the various image structures.

Ease of Data Evaluation

The CT image can be Zoomed to magnify a small area of the image and the window and leveling of the image gray scale is easily controlled to enable the detailed visualization of the CT image to discern very subtle difference in density information for detailed tumor structure analysis.

The graphical utility allows modification of all point locations, structure definitions, tumor volumes and provides the ability to strip away extraneous structures from the CT image such as bite blocks, head holders or the table image.

Ease of Treatment Planning Parameter Specification

The software is specifically designed with the user in mind. Our long experience with clinical use at many installed sites has given us an understanding of the requirements of the everyday user. While offering the most advanced 3D capabilities, the systems also still performs the more basic daily tasks in a simple, fast and understandable manner.

The special mnemonic keyboard capability is maintained while adding the use of a mouse to easily manipulate all of the beam treatment parameters quickly efficiently and graphically in the most comprehensible fashion.

Ease of Irregular Field Definition Using Beam’s Eye View

The COMPUTERx-PLAN® PC-3D™ Beam’s Eye View (BEV) allows the accurate evaluation of beam placement relative to the patient, all of the associated structures and the tumor volume from the view point of the radiation source through the collimator

This enables the manipulation of the field shape, position and angulation to provide real time virtual simulation to encompass the defined tumor volume as accurately as possible.

Irregular fields may also be optionally entered from the digitizer film input and then recalled and incorporated into the plan.

Ease of Orientation Comprehension

The difficulties of view and orientation comprehension are simplified by providing images of the familiar gantry, table and collimator showing their real physical orientation. These images are combined with a view as seen from any position in the room (the “Room’s Eye View”).

Super Graphics

High resolution SuperVGA graphics are utilized to provide the detailed viewing of the evolving treatment plan and the COMPUTERx-PLAN®-PC3D™ combines the high resolution SuperVGA graphics with the three-dimensional viewing of the patient anatomy from any direction or orientation

Data acquisition is enabled through the direct input of CT information from any of several modalities including Tape, disk, Local Area Network as well as Film scanners. Also, more routine input via digitizer, mouse and keyboard is possible in all of the Compute-Rx-Plan systems.

Superior 2D and 3D Imaging on the PC

Use of special software enable the PC to provide superior resolutions of up to 1024x768 which approaches the image quality generally reserved for only the most expensive systems. These capabilities easily allow full display of all of the 512x512 CT information and allow complete full windowing and leveling.

These high quality CT images are used to superimpose the dose distribution information to give the dosimetrist and radiotherapist the best comprehension of the results of their 3D treatment planning efforts relative to the patient structures.

Complete Body Surface Contouring

Unique to COMPUTERx-PLAN® PC3D® is the ability to accept full patient body surface contouring by special input from the COMPUTER-COMP® tissue compensator measuring and fabrication system’s data files. This allows simple single plane contouring for 2D planning as well as full three-dimensional body contouring for 3D treatment planning.

Special Irregular Field Calculation Features

COMPUTERx-PLAN® can easily calculate accurate doses and treatment times or monitor units for any complex irregular field.

The irregular fields that are used for the irregular field calculations can subsequently be imported into any of the COMPUTE-Rx-PLAN® treatment planning systems for inclusion in the external beam plan.

COMPUTERx-PLAN® has the unique capability of automatically being able to oppose a field and record the sum dose at every point from both of the opposed fields.

COMPUTERx-PLAN® also has the unique capability of being able to automatically add a compensator to an existing irregular field and calculate the dose distribution with the addition of the compensator.

Multi-Station Planning

The comprehensive CT viewing capability combined with optional remote workstation configuration can allow the physician to independently specify treatment volumes while the dosimetrist is planning the configuration of beam shapes and placements for the best possible dose distribution to the specified treatment volumes.

The COMPUTE-Rx-PLAN® PC3D® implements a complete analysis of the beam as shaped by asymmetric jaws, multi-leaf collimators or special beam shaping devices to provide the best possible accuracy under the widest possible treatment parameters.

The algorithms are specifically selected and programmed to give the fastest possible throughput while retaining the accuracy necessary for clinical radiotherapy treatment planning.

Pixel by Pixel Heterogeneity Corrections

The algorithms are capable of pixel by pixel density corrections throughout the entire 3D patient CT data set and incorporate special ray tracing algorithms that trace the beam path in all directions through the volume and through all heterogeneities in all directions.

Accuracy of CT Density Calculations

A special capability is provided to allow the specification of the CT number to electron density relationship. This special and unique capability is necessary to enable to most accurate dose calculations possible from the available CT information and is not possible or assumed on many other CT planning systems. Specifying and editing the relationship is uniquely simply and accurate in the COMPUTE-Rx-PLAN® PC3D® system.

Complete Volumetric Dose Consideration

The overall dose distribution is considered to be the results of many dose distribution modifying parameters. The algorithms independently consider all possible dose modifying parameters and then recombine the results into a very accurate representation of the dose distribution.

1) This includes patient related parameters such as surface obliquity and volumetric inhomogeneities that are within the patient as well as modifiers that are outside the patient like bolus, wedges or compensators.

2) This includes machine related parameters such as beam energy, field size dependence, beam flatness and collimator scatter contribution.

3) This includes field related parameters such the field’s shape, the block transmission and edge correction factors and scatter distribution related to the field shape as well as scatter modifications caused by lateral inhomogeneities, air flash and block edges.

All of these various dose distribution determining factors are used in a convolution algorithm to define the final dose distribution in the patient and the results are compared with measured beam data for similarly calculated fields and precisely conformed to provide the most accurate dose distribution algorithm possible --- and this most accurate calculation model is available on the PC platform --- today

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All of these many special capabilities combined with the exclusive SIMULTASKING™, make the COMPUTERx-PLAN® system especially unique in combining the very fastest PC calculations with the greatest ease of user interaction to give you fast, accurate, complete 2D radiation therapy treatment planning capability at a very reasonable cost.

Microprocessor:

• Pentium processors
• 450Mega Hertz
• 128 Mega bytes RAM*
• 8.2 Giga bytes Hard disc capacity

Peripherals:

• 20 x 24 surfacelit digitizer
• RGB analog Super VGA monitor
• Color laser printer/plotter

Options:

• Film scanner
• Beam data scanner and phantom
• Computer-Comp tissue compensator
• Multiple work stations
• Local Area Networking

* NOTE: Disc capacity, ram storage, processor speed, and other options may be specified to the user’s requirements for facility work load and capacity and budgetary allowances.

MEDICALIBRATION, Inc.

THIS COMPANY started in the late 60’s with simply “medical calibration” of therapy accelerators and clinical consultation in a wide area of clinical facilities. Our many years of direct clinical experience in assisting many facilities in providing accurate dose delivery has grown to include the development of several computer software applications which are intended to facilitate the accurate application of radiation to patients everywhere. In 1984 we incorporated to become MEDICALIBRATION, to specifically develop computer capabilities for radiation therapy and to enable this company to grow and continue to exist for you. In recent years we have carefully expanded out market to Europe where we are developing a growing family of users of out Compute-Rx-Plan as well as the Compute-Rx-Comp systems. Our many years of clinical radiation therapy physics experience and our growing staff of qualified personnel have made this company unique in its ability to address the practical needs of your entire radiation therapy department.

Since the late 60’s we have proven that you can depend on us: past, present and for years to come !

MEDICALIBRATION has been here for you and your patients, proudly bringing you quality radiation therapy computer planning capabilities at a reasonable price for over a decade,

MEDICALIBRATION is here for you today, bringing you the very latest capabilities in competent, reliable radiation therapy treatment planning and

MEDICALIBRATION will be here for you, with reliability and assurance, continuing into the 21st century supporting you in your radiation therapy computing software needs.